To observe the therapeutic effect and safety of Chuanxiong Qingnao Granules in the treatment of migraine with wind wetness and blood stasis syndrome.Methods:A total of 496 patients diagnosed with migraine with wind wetness and blood stasis syndrome were included in this research by the method of observational study.A multicenter，large sample，observational study was conducted for 2 weeks to observe the improvement rate of headache onset，onset time，headache attack and so on.Results:after two weeks′ treatment，the 481 patients of migraine treated with Chuanxiong Qingnao Granules had no obvious change in headache frequency，but degree of headache (VAS score) and headache days became lower than before treatment，and the differences were statistically significant (P<0.05); Follow-up duration patients with 4 years or less showed that the non-onset percent of the patents who had the disease more than four years′ patients was>70% after stopping treatment for two weeks.Drugs′ accumulated effective rate was 54.1% after five day′s treatment; The period of evaluation，drug average effective time was 2.36 hours; And the amount of patients who took painkillers were significantly reduced，and the difference was statistically significant (P<0.05).Conclusion:Chuanxiong Qingnao Granules can significantly reduce the symptom of headache，it also takes less time to become effective，and it has no obvious adverse reaction and good safety，which is worth of popularization in clinical practice.