To explore the clinical studies of Sofren injection on treatment with massive cerebral infarction,provide reference for its treatment.Methods:A total of 60 patients with massive cerebral infarction,were randomly divided into control group and observation group,30 cases in each group.The control group were treated by conventional therapy,Including the dehydration of intracraninal pressure，platelet aggregation，neurotrophic agent，etc，at the same time control of blood pressure，blood sugar，blood fat.Observation group was given conventional treatment and Sofren injection.After one course of treatment,case fatality rate，clinical curative effect，hemorheology changes,oxidative damage change，Imaging changes and security of two groups were observed.Results:Observation group mortality was 13.33%，control group was 30.00%，but there was no statistically significant difference（χ2=2.45；P>0.05）.Observation group of patients treatment the total effective rate was 66.67%，significantly higher than the control group 33.37%（P<0.05）.Observation group of patients than whole blood viscosity，fibrinogen，plasma specific viscosity，erythrocyte pressure water，significantly lower than the control group，the difference was statistically significant（P<0.05）.Observation group with SOD were significantly higher than control group，the MDA level were significantly lower the control group（P<0.05）.No serious adverse reaction in both groups，high safety.Conclusion:The Sofren injection on treatment with massive cerebral infarction effect is good,worth clinical promotion.