To evaluate the effects of YangXinShi tablet in treating coronary heart disease with qi deficiency and blood stasis syndrome.Methods:A total of 96 patients who were diagnosed with coronary heart disease complicated with qi deficiency and blood stasis syndrome were randomly divided into YangXinShi group and control group，48 cases in each group.The control group were given western medicine treatment，while the observation group oral administration of YangXinShi tablet on the basis of the treatment in the control group.After three months′ treatment，the clinical symptoms of Chinese medicine，angina pectoris，electrocardiogram，hs-CRP，NT-proBNP，Hcy，blood lipids and adverse reactions of all patients were detected.Results:After treatment,1) the total effective rate of improving Chinese medicine symptoms in YangXinShi group(92.8%) was significantly higher than that of control group (75.1%) and the difference was statistically significant (P<0.05); 2) the total effective rate of improving angina pectoris in YangXinShi group (93.75%) was significantly higher than that of in control group (83.33%)，P<0.05); 3)the total effective rate of improving electrocardiogram in treatment group (81.25%) was significantly higher than that of in control group (70.83%)，P<0.05; 4)the hs-CRP，NT-proBNP and Hcy in YangXinShi group were ［(1.21±0.27)mg/L，(597±171)ng/L and (7.24±0.46)μmol/L］ respectively，significantly lower than that of in control group ［(1.58±0.37)mg/L，(898±151)ng/L and (8.93±0.45)μmol/L］，P<0.05; 5) the incidence of adverse reactions in YangXinShi group (8.33%) was significantly lower than that of in control group (14.58%)，P<0.05.Conclusion:YangXinShi tablet combined with western medicine on coronary heart disease with qi deficiency and blood stasis syndrome was better than the conventional western medicine treatment alone.