To evaluate the efficacy of Kidney Tonifying and Stasis Removing Method with Thalidomide in treatment of multiple myeloma. Methods:A total of 120 patients with multiple myeloma were divided into two groups. The control group received VAD treatment, the observation group received Kidney Tonifying and Stasis Removing Method on the basis of the control group. Results:After treatment, the total effective rate of observation group was 75%, significantly better than the control group′s 60%. As for the indicators such as M protein, bone marrow plasma cells, osteoblasts and osteoclasts, the two groups met significantly drop but the observation group had significantly better results compared with the control group (P<0.05). On renal function, life quality and side effects, the observation group had less negative effects than the control group. Conclusion:The efficacy of Kidney Tonifying and Stasis Removing Method with Thalidomide in treatment of multiple myeloma is clear, and with fewer side effects and better quality of life after treatment, which has great clinical value, and is worthy of clinical promotion.