To study the effects of Lishi Huoxue formula (LSHX) on blood uric acid and antioxidant capacity of hyperuriceamia rats. Methods:Male SD rats were randomly devided into 7 groups:blank group, model group, Simiao pill group, Benzbromarone group, and LSHX groups (7.74 g/kg，3.87 g/kg and 1.935 g/kg). Except the blank group, the rest groups were administered with yeast extract and adeline intragastrically for two weeks to build hyperuriceamia models. After that, drugs were administered to the rats in corresponding group, and the blank group and model group were given distilled water for 14 days. Then the levels of UA, MDA, SOD, ROS, T-AOC, GSH-PX, CAT in serum were detected. Results:1) Compared with the blank group, serum UA content of the model group increased greatly with significant difference (P<0.001). ROS level increased too (P<0.001), and also with the content of MDA (P<0.01). On the other hand, the activity of SOD and T-AOC were obviously lower with significant difference (P<0.001). 2) Compared with the model group, levels of serum UA in Simiao pill group, Benzbromarone group, LSHX 7.74 g/kg and LSHX 3.87 g/kg group were obviously lower, and the difference of Benzbromarone group and LSHX 7.74 g/kg group was statistically significant (P<0.001, P<0.01). The MDA content of Benzbromarone group and LSHX 7.74 g/kg group were significantly lower than that of the model group, with significant difference (P<0.05). Except Simiaowan group, the SOD activity of the other groups was obviously higher, with significant difference (P<0.001). Besides, the ROS level of each drug group decreased, Benzbromarone group (P<0.001), LSHX 7.74 g/kg and 3.87 g/kg groups (P<0.01) dropped with great significance. Serum T-AOC activity of Simiao pill group, Benzbromarone group and LSHX 7.74 g/kg and LSHX 3.87 g/kg was obviously higher than that of the model group, and the difference between Benzbromarone group and the model group was statistically significant (P<0.001), also between LSHX 7.74 g/kg and LSHX 3.87 g/kg groups and model group (P<0.01, P<0.05). Conclusion:The Chinese herbal compounds LSHX can reduce the hyperuriceamia rat′s blood uric acid, and improve antioxidant and free radical scavenging capacities in hyperuricemia rats by clearing dampness and heat and removing stasis and stagnation. The Chinese herbal compound LSHX has a great therapeutic effect.