To analyze the experience and idea about earlier-and later-decocted formula in Wushi′er Bingfang, thus providing herb processing and cooking reference in clinical practice based on literature review. Methods:Centering on the special processing method:earlier and later-decocted, to select representative formula in analysis, discussion and comparison between modern formula. Conclusion:The recorded methods and processing procedure of Chinese materia medica (CMM) in this books could give insights to reasonable usage of CMM. Besides, more modern experiments and observations must be carried out to validation and further clinic application.