To observe the protective effect and safety of Danhong Injection (DHI) in combination with western medicine for PMI following elective PCI through systematic review.Methods:A systematic review of RCTs of DHI for the treatment and prevention of PMI following elective PCI were conducted on the basis of Cochrane,Medline,CNKI,VIP,CMCI and Wanfang.Data included the founding year to 31 Jan,2017.Two researchers independently selected the articles and extracted data.Then the quality was assessed and results cross-cheecked.Revman 5.3 was used in the analysis of the results.Results:Eleven RCTs that enrolled 956 patients were included.All were conducted in China.The control group(C,471 cases) was given conventional western medicine,and treatment group(T,485 cases) was given Danhong injection on that basis.It implies that,1) Danhong Injection can decrease the occurrence of myocardial infarction.2) After PCI 24hr,Danhong Injection can lower down CK-MB level with statistical difference ［MD＝-6.46,95%CI (-8.57,-4.34),Z＝5.99，P<0.00001］;and the level of cTNI，with statistical difference ［SMD＝-0.36，95%CI(-0.68,-0.03),Z＝2.16，P＝0.03］.3)After PCI 24hr,it can reduce the level of hs-CRP ［SMD＝-0.53,95%CI(-0.70,-0.35),6.02，P<0.00001］ and the level of IL-6,［SMD＝-0.66,95%CI (-0.92,-0.40),Z＝5.02，P<0.00001］ with statistical significance.4) It can increase the level of SOD and decrease that of MDA.5) Decrease the level of ET.6) Decrease occurrence of cardiovascular disease without inducing further adverse reactions.Conclusion:DHI might be a potentially efficacious treatment of PMI following elective PCI.Nevertheless,its safety remains uncertain because of limited information.Owing to the fact that the overall quality of the studies was low,higher qualified RCTs are expected.