To observe the clinical effect of Mudan Granule combined with macobalamine in treating diabetic peripheral neuropathy(DPN).Methods:Fifty cases of diabetes II patients admitted in our hospital from July 2015 to December 2015 were collected and randomly divided into control group and treatment group,with 25 cases in each.Basic treatment including dietary regulation and regular medication were given to both groups,only with the difference of major medicine(Mudan Granule and macobalamine in the treatment group and macobalamine in the control group).Treatment lasted for 12 weeks.Nerve conductive velocity(NCT),TCSS,VAS,and TSS were recorded before and after treatment.Also,serum fibrinogen and liver and kidney function indices were recorded to access the total effective rate.Results:After treatment,the scores of TCSS,TSS and VAS in stabbing pain,loss of sensation and burning pain were significantly improved in the treatment group,along with NCT and the level of serum fibrinogen.Comparing with the control group,the improvement is statistically significant(P<0.05).In addition,the total effective rate is significantly higher than that of the control group(P<0.05).Conclusion:Mudan Granule combined with macobalamine has a significant effect on relieving DPN symptoms especially in stabbing and burning pain-reliving.It can improve the living quality of patients,also secure and reliable,which can be promoted in clinical practice.