To explore the clinical curative effect of integrated traditional Chinese and western medicine treatment for patients with lumbar disc prolapse and its influence on serum inflammatory factors. Methods:A total number of 105 patients with pain due to lumbar disc prolapse were randomly divided into observation group (n=53 cases) and control group (n=52 cases). Two groups were both given fundamental therapies, including physical therapy and massage. Patients in the control group were given epidural closed treatment, while patients in the observation group were additionally treated with Shentong Zhuyu Decoction. Both groups received treatment for 2 weeks. The serum tumor necrosis factor alpha (TNF alpha), hypersensitive creactive protein (hs-CRP) and interleukin-6 (IL-6) level were observed in the two groups before treatment, 1 week and 2 weeks after treatment. VAS score and Japanese orthopedic society of low back pain score (JOA) and the clinical curative effect of treatment of the two groups before treatment, 1 week and 2 weeks treatment after treatment. Results:Serum TNF alpha, hs-CRP and IL-6 of patients in the two groups of after a week and 2-week treatment were reduced (P<0.05), compared with those before the treatment. The inflammatory indexes were lower in the treatment group than those of the control group (P<0.05). VAS and JOA score after a week and 2-week treatment was improved in both groups (P<0.05), but the improvement of the observation group was much more obvious than that of control group (P<0.05). The effective rate after a week and 2-week treatment was superior in the treatment group compared with that of the control group (P<0.05). Serious adverse drug events occurred in both the two groups during the treatment. Conclusion:Integrated Chinese and western medicine treatment may significantly inhibit inflammatory factors of patients with lumbar intervertebral disc prolapse pain, relieve the inflammatory state and alleviate patient′s pain and symptoms. The curative effect of this comprehensive treatment is satisfied, safe and reliable, worthy of clinical recommendation.