To explore the effect of Shenlingjianpiwei granule on gastrin and immune function in patients with chronic atrophic gastritis.Methods All 86 patients with chronic atrophic gastritis were randomly divided into a control group and an observation group，43 cases in each.Patients in the control group were given Folic Acid Tablets combined with convention drug therapy for treatment，whereas those in the observation group were treated with Shenlingjianpiwei granule combined with conventional therapy.The levels of gastrin，sIL-2R，CD4+T，CD8+T，CD4+T/CD8+T and therapeutic effect in the two groups were compared before and after treatment.Results After treatment，gastrin level in the observation group was (7.65±0.89)，significantly increased compared with that in the control group (5.12±0.53)，and the difference was statistically significant (P<0.05).After treatment，sIL-2R level in the observation group was (300.89±31.68)，significantly reduced than that of the control group (383.21 ± 38.92)，and the difference was statistically significant (P<0.05).After treatment，levels of CD4+T and CD4+T/CD8+T in the observation group were significantly increased than that of the control group，and the difference was statistically significant (P<0.05).CD8+T level in the observation group was much lower than that in the control group，and the difference was statistically significant (P<0.05).The total effective rate in the observation group was 95.35%，higher than the 74.42% in the control group，and the difference was statistically significant (P<0.05).Conclusion For patients with chronic atrophic gastritis，Shenlingjianpiwei granule is with satisfactory curative effect，which can improve the patients′ gastrin and immune function thus boost the therapeutic effect.