To compare Chinese medicine and estazolam treatment on sleep disorders in patients with hypertension for clinical reference and research.Method：The study selected 110 hypertension patients visited our hospital from October 2014 to January 2016，whom were divided into two groups through dynamic randomization methods.A control group，55 cases of hypertensive patients with estazolam treatment，and an observation group，55 cases of hypertensive patients with traditional Chinese medicine treatment and estazolam，to explore the systolic blood pressure，diastolic blood pressure，sleep disturbance score，adverse reaction rate differences after different methods of treating.Result：Through research data，it could be concluded that in the observation group，systolic blood pressure,diastolic blood pressure values were better than those of the control group (P<0.05).In the observation group，sleep quality score was (7.54 ± 2.54)，significantly lower than the control group (18.41 ± 2.55).In comparison of the incidence of adverse reactions，the results of the observation group were significantly lower than the results of the control group patients，(P<0.05)，and the difference was statistically significant.Conclusion:Chinese medicine and estazolam combination therapy has a certain effect on patients with hypertension，and it can effectively improve the patient′s sleep disorder and stabilize the patient′s condition，which has a high clinical value and is worthy of further application in clinical practice.