To analyze clinical effect of traditional Chinese medicine and moxibustion combined with western medicine in obese patients with infertility caused by with polycystic ovary syndrome.Methods:A hundred obese women with infertility induced by polycystic ovary syndrome were randomly divided into control group and experimental group according to randomized digital table.Patients in the control group were given conventional western medicine,while patients in the experimental group were treated with oral Chinese medicine,moxibustion and western medicine.Treatment effect,hormone levels,and patient′s ovulation and pregnancy in the two groups after treatment were compared.Results:The total efficacy rate of patients in the experimental group (96.00%) was obviously higher than that in the control group (54.00%),with statistical significant difference (P<0.05).Follicle stimulating hormone (5.19 ± 0.26) IU/L,luteinizing hormone (1.84 ± 0.31) IU/L,estradiol (0.43 ± 0.07) mmol/L in the experimental group were significantly superior to those in the control group (5.53 ± 0.19) IU/L,(5.53 ± 0.19) IU/L,(0.31 ± 0.05) mmol/L (P<0.05).The ovulation rate and pregnancy rate in the experimental group (96.00%,92.00%) were significantly higher than those in the control group (70.00%,62.00%),with significant difference (P<0.05).Conclusion:The combined treatment of traditional Chinese medicine,moxibustion and western medicine has obvious effect in treatment of obese patients with infertility caused by polycystic ovary syndrome and may significantly improve hormone levels and increase pregnancy and ovulation rate,indicating great clinical significance.