To investigate the efficacy of TCM differential treatment on puberty dysfunctional uterine bleeding of spleen deficiency type and to enrich treatment.Methods:Taking 102 adolescent patients with dysfunctional uterine bleeding spleen type hospitalized from December 2011 to November 2013，all were divided into two groups，51 cases in the control group with oral application of progesterone capsules，51 cases in the observation group with Yiqihuayu formula and Bushenguchong decoction treatment，and changes in relevant indicators were observed after treatment.Results:The cure rate of control group was 19.61%，the total efficiency 84.31%，and the cure rate of observation group was 41.18%，the total efficiency 96.08%.The observation group had significantly higher cure and total efficiency rate (P<0.05); two groups before and after treatment in hemoglobin and fibrinogen was not statistically significant (P>0.05)，and after treatment the thromboxane A2 significantly decreased (P<0.05)，plasma p concentrations and D-dimer after treatment increased (P<0.05).For the observation group，the difference of thromboxane A2 and D-dimer before and after treatment was not significant (P>0.05)，but p plasma concentrations increased more significantly (P<0.05); hemostasis time of observation group was significantly shorter than the control group (P<0.05).As to 1 year rebleeding rate and incidence of adverse reactions rate，the control group 23.53% and 9.8%，respectively，the observation group 11.76% and 1.96%,those of the observation group was significantly lower than those of the control group，and the difference was significant (P<0.05).In the observation group，total effect on individual symptoms like were vaginal bleeding，bleeding times，abdominal pain，palpitations，shortness of breath，were significantly higher than the other group，and the difference between groups was statistically significant (P<0.05).Conclusion:TCM differential treatment on puberty dysfunctional uterine bleeding of spleen deficiency type has clear efficacy.