To observe the effect of intravenous infusion of propofol anesthesia with seven isoflurane anesthesia on postoperative cognitive dysfunction elder patients after lower limb orthopedic surgery.Methods:A total of 60 elder patients with ASA I ~ II orthopedic operation were divided into two groups (blank control group and observation group),and the observation group was administered Yangxin Jiannao granules.After 1 day,3 day and 7 days′s operation,using mini mental state examination (MMSE) to assess cognitive function.Use ELISA kit for detection of spinal subarachnoid puncture catheterization success (T0),insert after laryngeal mask immediately (T1),after surgery (T2) 6 h,24 h (T3) and 48 h (T4) at different time points (a beta) 1-42.Results:The cognitive scores showed that in regards to MMSE score,the observation group were higher than those of the control group,and the preoperative comparison differs significantly(P<0.05).ELISA results showed that,after surgery (T2) 6 h,24 h (T3) and 48 h (T4) and t0 comparison,two groups of patients after 6 h of amyloid beta (1-42) protein levels both increased significantly(P<0.05).In regards to postoperative 24 h A-beta (1-42) protein levels,the observation group was significantly lower than that of the control group (P<0.05).Conclusion:Yangxin Jiannao decoction can significantly reduce postoperative cognitive function of the patients,reduce the release of biological markers,and can be used for clinical application.