To observe the effect of traditional Chinese medicine decoction combined with western medicine on serum total bile acid in patients with gallstone disease and the prognosis.Methods:To collect 148 cases of cholelithiasis patients of liver Qi stagnation syndrome in the central Hospital of Shanghai.The patients were then randomly divided into 2 groups,each group of 74 cases.All patients were treated by surgery.After the operation,the observation group was treated with traditional Chinese medicine Xiao Chai Hu decoction,and the control group received postoperative routine medical treatment.The course of treatment was 2 months.Liver function (ALT,AsT,TBiL) and total bile acid were detected before(1-3 days) and after treatment(the first and 2 months after treatment )respectively.To observe the therapeutic effect (the index of total effective rate) and the prognosis of patients (the index of recurrence rate).Results:After treatment,the symptoms including hypochondriac pain or abdominal pain were relieved or eliminated,and syndrome of liver depression qi stagnation was improved.The difference in total clinical efficiency between 2 group was statistically significant (P<0.05).After first and the second month,liver function,serum TBA concentrations in all patients were significantly lower than their preoperative levels.In the observation group,the difference in above indexes after treatment (P<0.05) and at each point (P<0.05) compared with the control group were all statistically significant (P<0.05).The follow-up rate was 93.92% (139/148),and the recurrence rate was 2.16%.Conclusion:Combined use of Xiao Chai Hu decoction with western medicine in patients with gallstone can regulate the concentration of total bile acid in serum to inhibit the formation of gallstones,which has a positive clinical significance for preventing gallstone and reducing recurrence rate.