To discuss the curative effect of acupuncture Huiyang Jiuzhen-acupoints and Jiawei Buzhong Yiqi decoction in treating patients with acute cerebral infarction. Methods:Sixty patients with acute cerebral infarction enrolled from January 2014 to June 2015 in our hospital were randomly selected and divided into two groups with 32 patients in each. The control group was treated with ozagrel sodium on the basic of depressurizing by dehydration, preventing platelet aggregation, maintaining brain with protectant, and treating symptomatically. The observation group was treated with acupuncture Huiyang Jiuzhen-acupoints and Jiawei Buzhong Yiqidecoction on the basic of the control group. Compared the clinical effects, neurological function deficits scale (NDFS) and activities of daily living (ADL) with two group and detected the levels of ET and NO in blood plasma before and after treatments. Results:The clinical efficacy rate was 90.63% in the observation group, which was higher than that of the control group, and differences were statistically significant (P<0.05). The score of NFDS was (13.31±6.58) in observation group after treatments which was lower than that of the control group, with statistically significance (P<0.05). The score of ADL was (54.39±8.67) in observation group after treatments which was higher than that of the control group, with significant difference (P<0.05). The levels of ET in blood plasma in observation group was (72.19±10.37)pg/mL while that of the control group was (83.26±11.58)pg/mL, and differences were statistically significant (P<0.05). The levels of NO in blood plasma in research group was (78.52±14.25) pg/mL, compared to (70.73±10.64) pg/mL of the control group, the differences were statistically significant (P<0.05).Conclusion:Acute cerebral infarction in treatment of acupuncture Huiyang Jiuzhen-acupoints and Jiawei Buzhong Yiqidecoction can adjust the levels of ET and NO, improve the function of vascular endothelial cell, promote the recovery of eurological impairment and enhance the patients′ quality of life with exact effects, which is worthy of clinical use.