To optimize formation technology of Xinnaosu granules. Methods:A single factor and orthogonal experiment was designed. The particle moisture absorption rate, the forming rate and the repose angle were taken as judging conditions to optimize the type and dosage of auxiliary materials and the concentration of wetting agent. To determine the optimum molding processes conditions. Results:The dextrin was optimized as excipient. Prescription of the clear cream and excipient was set as 1:1 and 90% ethanol was set as wetting agent. The drying temperature was set as 60 degrees centigrade. Conclusion:Xinnaosu Granule prepared by this method has stable properties, excellent appearance, few moisture absorption and good dissolubility. This method can be utilized in industrial manufacture.