Inflammatory bowel disease (IBD),including crohn′s disease and ulcerative colitisis,are chronic inflammatory diseases with unclear etiology and pathogenesis.The effect of acupuncture and moxibustion on the treatment of IBD is curative and has significant advantages,but its mechanisms still need to be further studied.Studies in recent years found that lncRNAs widely involved in the physiological and pathological process of the body,especially mediating the immune inflammatory response through gene regulation,and have close relationship with variety autoimmune diseases that including IBD.A variety of lncRNAs differently expressed when IBD occurs,and the abnormal expression and function of lncRNAs play an important role in the development of IBD inflammation.In this article,the functions of lncRNA as well as research progress of its relationship with IBD are summarized,and then base on the treatment of acupuncture and moxibustion on IBD,we in order to study whether acupuncture and moxibustion regulate the inflammatory response of IBD through regulating related lncRNAs,which will provide new ideas for the research on the mechanism of acupuncture and moxibustion on the treatment of IBD.