Cancer-related fatigue is one of the most distressing symptoms which affects the functional status and quality of life of cancer patients in late stage.Acupuncture and moxibustion gain popularity in the management of cancer-related fatigue for its effective treatment with little side effect.By retrieving relevant medical literatures from VIP，CNKI，Wan Fang，PubMed and Cochrane Library databases，the article reviewed progress in basic and clinical research of acupuncture and moxibustion for cancer-related fatigue over the past decades and evaluated its efficacy.Meanwhile，this article also analyzed its potential mechanisms and pointed out the existing problems in the previous research，which needs further research and application.