Arrhythmia is common, which is an important cardiovascular disease and a usual disease associated with others. Palpitation is a clinical symptom. TCM used unique methods to treat palpitation with a long history and good clinical effect. Based on the syndrome differentiation of zang-fu viscera, this paper discusses the mechanism and therapy on the palpitation from 5 aspects according to main Chinese ancient literatures, treating from the lung, the liver, the spleen and stomach, the kidney and the gall bladder. And in the treatment of palpitation, nourishing the heart should be the first, and according to the syndrome differentiation of zang-fu viscera choose therapy of clearing heat, warming Yang, activating blood circulation or resolving phlegm and others. The treatment should be based on syndrome differentiation rather that theories of the book.