To evaluate the efficacy of combined treatment to mycoplasma pediatric pneumonia and the effectiveness and safety of TCM. Methods:The clinical experiment is a multi-centered, prospective cohort study. According to different treatments, western medicine group and TCM integrated with western medicine group were naturally set up. Western medicine treatment group were given azithromycin. While on this basis, integrated group was treated by TCM internal and external medication. Results:The cure rate of western medicine group was 18.9%, significant efficiency was 78.9%, and the effective rate 100% (n=90). The cure rate of the integrated group was 31.9%, significant efficiency rate 76.8%, and the effective rate 100% (n=310 ). Cure rate between the two groups has statistically significant difference (P<0.05). However, no significant difference exist in regards to significant efficacy rate and effective rate between the two groups (P>0.05). Conclusion:Intergrated Chinese Medicine with Western Medicine has higher efficacy rate.