To discuss clinical effects of Qi-Replenishing Mass-Dissipating Formula and entecavir in the treatment of decompensatory hepatitis B cirrhosis.Methods:A total of 64 patients with decompensatory hepatitis B cirrhosis were selected and divided into treatment group and control group (n=32).The control group were treated with liver protective,symptomatic and supporting treatments while the other 32 patients in treatment group treated with Qi-Replenishing Mass-Dissipating Formula and Entecavir on the control group’s treatment.And the levels of ALT,AST,TBil and ALB in two group before and after treatments,the PVD,SVD,PVQ and SVQ in two group before and after treatments were evaluated.Child-Pugh before and after treatments were graded,and disappearance rate of peritoneal dropsy were compared.Results:The levels of ALT,AST and TBil in treatment group were lower than the control group after treatments,differences were statistically significant (P<0.05）;The level of ALB after treatments in control group was higher than that in control group,difference was statistically significant (P<0.05）;The PVD,SVD,PVQ and SVQ after treatments in treatment group were lower than the control group,differences were statistically significant (P<0.05）;The scores of Child-Pugh after treatments in treatment group were lower than control group,differences were statistically significant (P<0.05）; The negative conversion rate of HBV-DNA and disappearance rate of peritoneal dropsy after treatments in treatment group were higher than control group,differences were statistically significant (P<0.05）.Conclusion:Qi-Replenishing Mass-Dissipating Formula and entecavir treatment can help prevent the virus replication,and improve the clinical symptoms and liver function when treating decompensatory hepatitis B cirrhosis,which is worth of clinical usage.