To observe the change of procalcitonin (PCT) and C-reactive protein (CRP) in patients with acute pancreatitis after the treatment of Dachengqi decoction combined with somatostatin, then discussing the clinical curative effect of Dachengqi decoction on acute pancreatitis. Methods:Fifty cases of patients with acute pancreatitis in our hospital were randomly divided into two groups, with 15 cases given conventional treatment (eg:octreotide) in control group，and 30 cases given Dachengqi decoction by gastric tube in treatment group on the basis of the control group treatment. After treatment of 1 d, 3 d, 7 d, patients in two groups were immediately drew blood and detected the level of PCT and CRP. At the same time, white blood cell count and blood amylase examination were counted and conduced to analyze the two groups’ survival times, first time defecation, and hospitallization duration. Results:After treatment, the differences of PCT,CRP, WBC count and blood amylase between the two groups have statistical significance (P<0.05). In terms of first time of defecation, hospitalization stay, the two groups have obvious differences (P<0.01). Conclusion:Dachengqi decoction combined with somatostatin can obviously decrease PCT and CRP, regulate the function of endocrine of pancreas, and inhibit inflammatory cytokines. It can function cohesively with somatostatin, and be used as one of the methods in treating acute pancreatitis.