To discuss Tangshen Guanchang Decoction clinical curative effect for the treatment of diabetic nephropathy renal insufficiency. Methods:Ninety-four patients with renal insufficiency due to diabetic nephropathy who received treatment in the hospital from June 2014 to October 2015 were selected and randomly divided into treatment group and control group,according to random number table method. Patients in both the two groups were given low salt-fat and high protein diet,insulin to control blood sugar and ARB antihypertensive drugs. Patients in the treatment group additionally adopted Tangshen Guanchang Decoction on the basis of the above treatment,while patients in the control group were treated with Shenshuaikang enema for 3 months. Blood glucose,blood pressure,24 hours urinary protein,renal function,plasma albumin and quantitative TCM symptom score of patients in the two groups before and after treatment were observed. Results:Total effective rate for the TCM symptoms of the treatment group was obviously better than that of the control group. Laboratory indicators of the treatment group improved obviously after the treatment,while improvement of the control group after treatment was not obvious. Symptoms integral of the treatment group after treatment decreased significantly,while that of the control group was not obvious. Conclusion:The curative effect of Tangshen Guanchang Decoction combined with western medicine in treating renal insufficiency due to diabetic nephropathy of is better than that of r Shenshuaikang enema combined western medicine therapy and may effectively reduce lab indicators,improve patients’ nutritional status and renal function,relieve dropsy,and enhance patients’ quality of life.