To observe the efficacy and safety integrative traditional Chinese and western medicine chemotherapy in the treatment of tuberculosis in older people. Methods:A total of 100 older patients with tuberculosis treated in our hospital from January 2015 to January 2016 were randomly divided into two groups. The control group was treated with 2HREZ / 4HR chemotherapy regime. The study group was treated with 2HREZ / 4HR program with traditional Chinese medicine. Compare the clinical efficacy and safety of the two methods after 4 months of treatment. Results:The total effective rate was 80.00% in the control group and 94.00% in the study group, with P<0.05. Besides, the negative rate of sputum smear in the study group was higher than that of the study group (P<0.05). The number of white blood cell abnormalities in the study group was lower than that of the control group and the gastrointestinal discomfort level was lower in the control group (P<0.05). Conclusion:Chinese medicine combined with 2HREZ / 4HR can be used in treating tuberculosis in older patient with lower liver injury rate and higher recovery rate. It is safe and time-efficient, which has remarkable clinical effect.