To observe the clinical efficacy of Jianpi Yiqi decoction combined with Acu-points application in the treatment of postprandial discomfort syndrome. Methods:A total of 121 patients with postprandial distress syndrome were randomly divided into three groups：41 cases in western medicine group (domperidone treatment), 40 cases in Chinese medicine group (treated with decoction), 40 cases in Chinese medicine combined group (decoction combined with Acu-points application). After 28 days of treatment, observe the improvement situation of different groups. Results:1)No significant difference in symptom score was found among the three groups pretreatment. (P>0.05). After treatment, symptom scores of combined group was significantly lower than that of the Chinese medicine group and Western medicine group (P<0.05); 2) Total effective rate of the combined group was 92.5%, Chinese medicine group 82.5%, and the western medicine group 80.5%. Comparison showed that the clinical curative effect of combined group was better than that of the other two groups (P<0.05). Conclusion:Jianpi Yiqi decoction combined with Acu-points application has significant efficacy in treating postprandial discomfort syndrome, and is better than the effect of western medicine.