To observe the efficacy and safety of leonurus injection combined with Gedan and Xinmu Pei in hemorrhage of placenta previa cesarean section. Methods:Forty-six patients diagnosed as placenta previa who need elective cesarean delivery in our hospital admitted from July 2015 to October 2016 were collected. According to different ways of postpartum hemostasis, 46 patients were divided into experimental group and control group, with 23 cases in each group. After surgery, the experimental group were immediately injected with leonurus injection 2 mL+Xinmu Pei 250 μg. Gedan 50 mL was given to rinse the uterine cavity for 1 min. The control group was injected with leonurus injection 2 mL+Xinmu Pei 250 μg, and the uterine cavity was rinsed for 1 min with 0.9% sodium chloride injection 50 mL. The bleeding status and hemostasis effect were observed in 2 groups. The levels of hemoglobin (Hb), erythrocyte count (RBC) and plasma prothrombin time (PT) and thrombin time (TT) were measured before and after operation. The patients were followed up for 42 days to collect the incidence of postpartum complications, adverse reactions and uterine recovery situation. Results:The amount of intra-operative blood loss, postoperative 2 h, 24 h vaginal bleeding, intra-operative blood transfusion were significantly lower in the experimental group than those of the control group (P<0.05 or P<0.01). The incidence of complications was lower in the experimental group than that of the control group (P<0.05), and the recovery rate of uterus in the experimental group was higher than that of the control group (P<0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Compared with presurgery and 24 h after surgery, Hb levels in the two groups were significantly reduced (P<0.05 or P<0.01), while the levels of RBC and PT, TT had no significant change (P>0.05). However, 24 h after operation, the levels of RBC and Hb in experimental group were significantly higher than those of the control group, and the difference was statistically significant (P<0.01), while PT, TT in the two groups had no significant difference (P>0.05). During follow-up, infants were all healthy and in sound status. Conclusion:Leonurus injection combined with Gedan and Xinmu Pei have obvious effect in treating hemorrhage of placenta previa cesarean section, can reduce the incidence of maternal complications and can improve the uterus after operation.