To evaluate the clinical effect of Yuye decoction in the treatment of type 2 diabetes with an attempt to provide evidences for the clinical treatment.Methods:Major online databases including PUBMED,CNKI,VIP, and Wan Fang medical network were searched for a period between the time that the database were built to 2014 09 01 to collect RCT studies on Yuye decoction in treatment of type 2 diabetes. Data were extracted for quality evaluation and analyzed by RevMan 5.3 software.Results:Nine RCT trials were included. A total of 756 subjects were enrolled. The meta-analysis showed that applying Yuye decoction in treatment of type 2 diabetes had effective value in improving symptoms and signs 〔R=1.97，95%CI：1. 46～2.66，Z=4.46,P<0.00001〕, total effective rate 〔OR=4.82, 95%CI：7.59～3.06, Z=6.78, P, 0.00001〕, which were remarkably higher than those of the control groups, with significant difference between control groups.Conclusion:Yuye Decoction was effective in the treatment of type 2 diabetes mellitus. The above conclusions still need further study in carrying out more large samples and confirming high quality studies.