To investigate the regularity of acupuncture and moxibustion treatment in diarrhea predominant irritable bowel syndrome (D-IBS) and constipation predominant irritable bowel syndrome (C-IBS). Methods:The research of acupuncture and moxibustion on D-IBS and C-IBS were collected from public databases including China National Knowledge Institute, Wanfang, VIP, Pubmed, Web of science etc. The approaches of acupuncture and moxibustion, the meridians and acupoints information was extracted. The differences in meridians and acupoints between D-IBS and C-IBS were studied by the descriptive analysis, correlation rule analysis clustering analysis. Results:A total of 56 research of acupuncture and moxibustion on D-IBS, and 6 research of on C-IBS were involved in this study. In the studies of D-IBS, acupuncture was the most usual approach. The acupoints at the stomach meridian and conception vessel, such as ST 25, ST 36, CV 12 were used mostly often. By the correlation rule analysis, the combination of stomach meridian, spleen meridian, and conception vessel in the meridian analysis, but ST 36, ST 25 h, LR 3 in the acupoints analysis were mostly common. The cluster analysis found out that there were 2 effective clusters, 2 pairs of meridians as well as 5 effective clusters and 5 pairs of acupoints. In the study of C-IBS, indirect moxibustion was the most usual approach in clinic. The acupoints at the stomach and bladder meridians such as ST 36, BL 25, ST 37, and ST 25 were found mostly. The correlation rule analysis and cluster analysis found similar results as D-IBS in the meridian acupoints, but ST 36 and ST 25 were mostly used. The cluster analysis found out that there were 2 effective clusters and 2 pairs of acupoints. Conclusion:Based on the analysis of acupuncture and moxibustion on D-IBS C-IBS, it was concluded that there is high similarity between the two diseases though there are different treating methods, D-IBS treatment often using combined acupuncture and moxibustion and C-IBS using moxibustion.