Alzheimer’s disease (AD) is a common neurodegenerative disease and its pathogenesis is related to oxidative stress induced by β-amyloid (Aβ). Aβ induces oxidative stress through three pathways,namely 1) binding to the receptor of advanced glycation end products (RAGE) on cell surface; 2) inducing oxidative stress by the 35th methionine residue (Met-35) of Aβ; 3) catalyzing the synthesis of free radical by inserting into lipid bilayer. Some classic herbal formulas,such as Di-Huang-Yin-Zi Decoction,Zuo-Gui Pill and Huang-Lian-Jie-Du Decoction,as well as contemporary empirical herbal formulas including Bu-Shen-Yi-Zhi Decoction,Huang-Jing-Di-Long Decoction and Huan-Nao-Yi-Cong Decoction,can inhibit generation of free radical,protect neurons from oxidative stress damage and thus contribute to AD prevention and treatment.