To discuss the clinical features of patients with sepsis-induced acute kidney injury(AKI) and the factors that affect prognosis. Methods:A total of 90 sepsis cases in Intensive Care Unit (ICU) of Beijing Hospital of Traditional Chinese Medicine from December， 2011 to December， 2016 were retrospectively analyzed. Simple and multiple logistic regression were used to analyze and study the clinical features and risk factors affecting prognosis. Results:A total of 42 sepsis cases were complicated by AKI. The mortality rate of cases with AKI was evidently higher than the rest without AKI (P<0.05). The analysis by simple logistic regression revealed that the major factors affecting the curing of AKI could be history of nephropathy， pulmonary infection， MODS， CRRT， intervention of Traditional Chinese Medicine and use of respirator. And the analysis by multiple logistic regression revealed that rising of MODS and pulmonary infection might increase the mortality risk. Conclusion:The amount of failure organs， and use of respirator can be taken as important reference for the estimates of the prognosis of patients with sepsis-induced AKI.