Multiple sclerosis (MS) is characterized by high relapse rate and high disability rate, and it is one of the causes for the young and middle-aged with disability, second only to trauma. In recent years, more researches has been focused on traditional Chinese medicine (TCM) in treating MS, and the researches of clinical practice on TCM in treating MS revealed that some new ideas had been brought by TCM to the prevention and treatment of neuroimmune diseases. Therefore, this article analyzes the unique role of TCM in treating MS, such as delaying, inhibiting and even terminating the relapse and progress of MS, relieving depression, cognitive dysfunction and neurological deficits, and finally enhancing the patients’ quality of life and satisfaction with life.