To analyze the effect of integrated Chinese and western medicine in treating sepsis patients and its clinical pathway. Methods:A total of 92 patients with sepsis admitted into our hospital from October 2013 to September 2015 were collected， then randomly divided into observation group (n=46) and control group (n=46). The control group was given conventional western medicine therapy， and on that basis， the observation group was given additional integrated Chinese and western medicine according to syndrome differentiation. Observe body temperature， heart rate， breathing， white blood cell count， the elf inhibition-C， oxygenation index， and so on before and after the treatment in both groups. Meanwhile， compare phlegm and blood culture results and clinical curative effects between the two groups. Results:After treatment， body temperature， heart rate， breathing， white blood cell count， the elf inhibition-C and oxygenation index of both groups were obviously improved， and the observation group was significantly better than the control group patients (P<0.05). After treatment， in the aspect of phlegm and blood culture， the total effective rate was 86.95% in the observation group， compared to 73.91% of the control group(P<0.05). Also， the results of total effective rate in observation group patients is significantly higher than that of the control group of the same period with statistical significance (P<0.05). Conclusion:Integrated western medicine and Chinese medicine has obvious curative effect on treating sepsis. It can relieve clinical symptoms and assist in prospective research， which is worthy of clinical population.