To investigate the effect of retention enema of traditional Chinese medicine on the treatment of chronic pelvic inflammatory disease and the level of inflammatory factors.Methods:Selecting 110 cases of chronic pelvic inflammatory disease，all of them were randomly divided into an observation group and a control group，55 cases in each.Both of the groups were treated with conventional anti-inflammatory therapy，and the observation group was treated with extra retention enema of traditional Chinese medicine.After a course of treatment，the groups were evaluated from clinical efficacy，inflammatory factors levels，recurrence and quality of life.Result：There was no significant difference in the age，course of disease，disease and other general information between the two groups (P>0.05).The total effective rate of the observation group (90.91%) was significantly higher than that of the control group (61.82%)，and the difference was statistically significant (P<0.05); after treatment，the serum levels of NF-α of the observation group significantly reduced (P<0.05)，and IL-2，IL-10 increased significantly，comparing with before treatment (P<0.05)，while the above three indexes of control group before and after treatment had no statistically significance (P>0.05); after treatment，there was statistical significance in observation group’s serum TNF，IL-2 and IL-10 level，comparing with the control group (P<0.05); as to the quality of life score comparison，except that there was no obvious difference in medicine dependence，all other scores of the observation group were better than those in the control group，and the difference was statistically significant (P<0.05).The recurrence rate in 6 months of the observation group was significantly lower than that in the control group (P<0.05).Conclusion:TCM retention enema has significant clinical effect in chronic pelvic inflammation patients.It can effectively improve the inflammatory reaction，reduce the recurrence rate for the first half of the year and improve the prognosis of patients，safe and reliable，with significant research meaning.