To study and explore the clinical curative effect of integrated traditional Chinese and Western medicine in treating senile herpes zoster，providing guidance for the clinical treatment.Methods:Totally 100 cases of elderly patients with herpes zoster hospitalized here from January 2013 to December 2015 were randomly selected as research objects，dividing into a control group and an observation group by the computer，each 50 patients.The control group was provided with conventional western medicine treatment，while the observation group integrated traditional Chinese and western medicine treatment.Results:The clinical total effective rate of observation group was 94%，and the recurrence rate was 6%; the clinical total effective rate of control group was 78%，and the recurrence rate was 20%.The differences between the two groups were statistically significant (P<0.05).Comparing with the control group，the observation group had much shorter pain relief time，bleb subside time and incrustation time (P<0.05) All patients’ sleep quality index，the scores of anxiety and depression scores were significantly improved than before treatment(P<0.05)，but the observation group improved more(P<0.05).In observation group，life quality score was (80.24±6.71)，significantly higher than the control group (P<0.05).Conclusion:In clinical treatment of elderly patients with herpes zoster，integrated traditional Chinese and western medicine treatment has significant clinical curative effect，and can effectively alleviate the clinical symptoms，reduce the recurrence and improve the prognosis.