To observe the clinical effect and safety of Kanglixin capsule combined with differentiated Chinese medicine in the maintenance of advanced colorectal cancer. Methods:Sixty-nine patients of advanced colorectal cancer with a response evaluation of CR， PR or SD after first-line chemotherapies were randomized into two groups. Patients in experiment group， 35 cases， were administered with Kanglixinin capsule combined with differentiated Chinese medicine， and those in control group， 34 caese， were administered with differentiated Chinese medicine only. Results:The median PFS was 7 months in the experiment group and 5 months in the control group， and there was significant difference (P=0.023). Conclusion:Kanglixin capsule can prolong PFS of patients and is a good choice in the maintenance of advanced colorectal cancer.