To investigate the effect of Tongxinluo(TXL)， rosuvastatin calcium tablets and bayaspirin in treatment of hyperlipidemia associated with carotid atherosclerosis. Methods:Sixty-four cases of hyperlipidemia associated with carotid atherosclerosis were divided into a control group (32 cases) and a treatment group (32 cases) by random number table method. The control group was treated with rosuvastatin calcium tablets and bayaspirin， the treatment group “Golden Triangle” program (TXL， rosuvastatin and rosuvastatin calcium tablets and bayaspirin)， and the course was 6 months. The blood lipid levels， homocysteine (Hcy)， high sensitive C-reactive protein (hs-CRP) level and carotid artery intima-media thickness (cIMT)， number and area of plaques of patients in the two groups before and after treatment were detected. And those data were compared again after 6 months. Results:After treatment， the blood lipid levels， Hcy， hs-CRP levels and cIMT， and number and area of plaques were significantly improved comparing with before， and the effect of the treatment group was better than the control group（P<0.05，P<0.01）. Conclusion:The treatment effect of “Golden Triangle” program of carotid atherosclerosis were better than the simple combination of rosuvastatin calcium tablets and bayaspirin.