To study and discuss the clinical effect of modified Huanglianwendan decoction on coronary heart disease and its effect on C reactive protein. Methods:From January 2013 to December 2015， 100 patients with coronary heart disease who were admitted to our hospital were selected as the subjects. The patients were randomly divided into control group and observation group. 50 cases in each. The control group was treated with conventional western medicine. The observation group was treated with extra Huanglianwendan decoction on the basis of the control group. The total effective rate， blood lipid index， cardiac function index， angina pectoris， C-reactive protein were compared between the two groups. Results:The total effective rate of the observation group was 94%， which was significantly higher than that of the control group， 78%， (P<0.05). Compared with the control group， the total cholesterol， triglyceride and low density lipoprotein cholesterol in the observation group were significantly lower (P<0.05)， and the high density lipoprotein cholesterol was significantly higher (P<0.05). After treatment， the left ventricular ejection fraction， NT-proBNP and 6-minute walking distance of the two groups were significantly improved (P<0.05). The duration frequency of angina pectoris was significantly decreased in the two groups (P<0.05). The levels of C-reactive protein in the two groups were significantly decreased (P<0.05)， and the difference between the two groups was statistically significant (P<0.05) ). Conclusion:In the clinical treatment of coronary heart disease， the therapy of modified Huanglianwendan decoction has significant clinical curative effect， which can reduce the blood lipid level and C-reactive protein content， reduce the onset of angina pectoris and improve the cardiac function of patients.