To observe the efficacy and safety of Children resuqing granules combined with antibiotic in the treatment of acute suppurative tonsillitis.Methods:A total of 300 children with acute suppurative tonsillitis were randomly divided into control group and observation group.Control group was treated with azithromycin;based on the treatment of control group，observation group was treated with Children resuqing granules，3~4 times a day.The treatment course was 5 d.The clinic data was observed，including clinical efficacy，average cooling time and throat disappear time，WBC，CRP level，and CD4+/CD3+，CD4+/CD8+and CD8+/CD3+in vivo before and after treatment and incidence of adverse reactions in 2 groups.Results:The total effective rate in observation group was significantly higher than control group，average cooling time and throat disappear time were significantly shorter than control group(P<0.05).After treatment，WBC and CRP level were significantly lower than before，and observation group was lower than control group;CD4+/CD3+was significantly higher than before，and observation group was higher than control group;CD4+/CD8+in observation group was significantly higher than before and control group，CD8+/CD3+in control group was significantly higher than before(P<0.05);however，there were no significant differences in the CD8+/CD3+in observation group before and after treatment，and incidence of adverse reactions between 2 groups (P>0.05).Conclusion:Based on the treatment of Children resuqing granules has better efficacy and safety in the treatment of acute suppurative tonsillitis.