To investigate the clinical effect of Xiaomi ointment on patients with cervicitis and its effects on cervical local human epidermal growth factor (EGF)， interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) expression. Methods:In total， 64 patients with cervicitis in our hospital from June 2015 to March 2016 were selected and randomly divided into an experimental group and a control group， with 32 cases in each group. Patients in the control group received microwave treatment， while patients in the experimental group were treated with Xiaomi ointment. The clinical efficacy rate of the two groups were collected， and the changes of cervical local IL-1 beta， TNF-alpha and EGF levels in the two groups were recorded and compared. Patients’ vaginal discharge time， scabby bleeding time， healing time， output and drainage volume in the two groups were also observed. Results:There was no significant difference in clinical efficacy between the two groups (P>0.05). Compared with the data before treatment， cervical local IL-1β and TNF-α levels in two groups both decreased significantly， while EGF levels increased (P<0.05) significantly. Cervical IL-1β and TNF-α levels in the experimental group were significantly lower than those in the control group (P<0.01)， while its EGF levels were significantly higher than those of the control(P<0.01). Conclusion:Xiaomi ointment can eliminate the cervicitis by increasing EGF levels and decreasing levels of IL-1β and TNF-α. Its efficacy is similar to that of microwave treatment， but it can effectively shorten the healing time of cervix and reduce the amount of bleeding and drainage in the treatment.