To investigate the clinical efficacy of combined treatment of traditional Chinese medicine(TCM)and non cyclic glycosides in the treatment of herpes simplex keratitis(HSK).Methods:A total of 67 patients with HSK from June 2014-2015 year in March the hospital treated patients(98 eyes)were randomly divided into control group，33 cases(47 eyes)and a treatment group of 34 cases(51 eyes)，the control group was given acyclovir treatment，the treatment group in the control group on the basis of the solution of poison treatment with traditional Chinese medicine Qi，2 groups were treated for 4 weeks.The clinical efficacy of the 2 groups were recorded and compared 2 groups of clinical symptom recovery time; change detection and comparison of 2 groups before and after treatment of corneal thickness，corneal sensitivity，T cells and related cytokines; regular follow-up 1 years after treatment were recorded and compared during follow-up of patients in the 2 groups.Results:After treatment，the total effective rate of control group was 72.34%，significantly lower than the treatment group(90.20% P<0.05); the onset time of the treatment group，corneal ulcer healing time，hyperemia subsided time，stimulation symptoms disappeared time significantly shorter than the control group(P<0.01); compared with before treatment，after treatment，2 groups of symptoms and signs score score and corneal thickness were decreased，and the treatment group was significantly lower than the control group(P<0.05 or P<0.01)，2 groups of corneal sensitivity were significantly improved，and the treatment group was significantly higher than the proportion of corneal sensitive control group(χ2=3.965，P=0.047); compared with before treatment，after treatment，the CD4+ ratio and CD4+/CD8+ ratio were significantly increased，and significantly higher than that of the control group(P<0.05); treatment group CD8+ significantly decreased and was significantly lower than the control group(P<0.05)，and control group CD4+，CD8+ ratio，CD4+/CD8+ ratio.Change(P>0.05).Compared with before treatment，after treatment，2 groups of serum interleukin 18(IL-18)and interferon gamma(IFN-gamma)levels were significantly increased，and the treatment group was significantly higher than the control group(P<0.05 or P<0.01).In 1 years of follow-up，the cumulative recurrence rate of control group was 43.33%，compared with 16.28% in the treatment group increased significantly(χ2=6.503，P=0.011).Conclusion:Yiqi Jiedu decoction combined with acyclovir in the treatment of HSK curative effect is significantly improved，the recovery time of clinical symptoms significantly shortened，corneal thickness，corneal sensation recovery，cellular immune function improved significantly，reduce the relapse rate，the curative effect was significantly better than acyclovir alone.