To study the comprehensive treatment of traditional Chinese medicine on total knee arthroplasty(TKA)perioperative analgesic efficacy.Methods:Selected in January 2015-December 2015 in our hospital artificial knee joint replacement of 60 patients with unilateral，randomly divided into 2 groups，30 cases in each group.Group A(control group)：use western medicine multimodal analgesia; Group B(experimental group)：on the basis of western medicine multimodal analgesia scheme，with comprehensive therapy of traditional Chinese medicine.Record each node in patients with preoperative and postoperative time stationary，visual analogue scale(VAS score)，knee joint is Lord，dynamic of motion(ROM)，knee joint function assessment(HSS score)，western medicine analgesia drug usage and adverse reactions.Results:Two groups of patients in the preoperative 3 d，postoperative 6 and 12 h，1，2，4，7，14，30 static，dynamic VAS score comparison，preoperative patients with 3 d，12 h after operation，1，2，4，7，14，30 static VAS score were less than group A，group B(P<0.05，with statistical significance，6 h after static VAS score results compare differences had no statistical significance(P>0.05); Patients with preoperative 3 d，postoperative 6 and 12 h，1，2，4，7，14，30 dynamic VAS score were less than group A，group B(P<0.05，with statistical significance.Two groups of preoperative 3 d，postoperative 1，7，14 d main joints and passive joints of motion(ROM)group B was better than group A，compare the difference was statistically significant(P<0.05)，the two groups after 30 d follow-up ROM value was no significant difference(P>0.05).Two groups of patients with postoperative 3，7，14，30 d，HSS score are better than that of group A，group B(P<0.05，with statistical significance.Group B of the incidence of adverse reactions and selective analgesic drugs usage was lower than that in group A.Conclusion:The combination therapy of traditional Chinese medicine combined with western medicine multimodal analgesia than pure western medicine multimodal analgesia scheme can more effectively reduce middle TKA postoperative pain，early functional exercise and restore joint function，and does not increase the incidence of related complications，selectivity and reduce postoperative analgesia drug usage.