To introduce the experience of Professor Zhang Tingdong on the treatment of leukemia with pyrexia. Pyrexia is the most common and prominent symptom of leukemia. In this area， Professor Zhang has accumulated lots of experience. He holds that the pathogenesis and the deficiency and excess of the syndrome should be analyzed firstly， based on the clinical situation. And the basic principle of syndrome differentiation is important， treating both symptoms and root causes. Then favorable efficacy could be achieved， combining Chinese and western medicine.