Pre-diabetes is a stage when patients had elevated blood glucose but not to diagnostic criteria. The cause and pathogenesis of high blood sugar at this stage should be analyzed through the theory of traditional Chinese medicine metabolism and “spleen hate”. Professor Wei applies the idea of preventive treatment for disease to explore the treatment principle for pre-diabetes. First，disease prevention，Wei focuses on reinforcing spleen and kidney，strengthening the transformation and transportation of the spleen and qi formation of the kidney. Second，prevention of the progress of the diseases，control the related factors and disease progress of pre-diabetes by regulating spleen and kidney，relieving dampness and phlegm，activating blood circulation，eliminating the visible evilness，like phlegm or blood stasis. The clinical effect is obvious.