To analyze the distribution characteristics of common syndromes and syndrome factors of xerostomia in literature researches and clinical investigations.Methods:Through selecting TCM literature about the syndrome differentiation of xerostomia from 2000-2015， build Epidata 2. 0 database and use SPSS 17. 0 to make descriptive statistical analysis.Results:In the aspect of literature research， the occurrence frequency of the following syndromes of xerostomia are higher than 10%：lung-yin deficiency， stomach-yin deficiency， yin deficiency with effulgent fire， liver-kidney yin deficiency， kidney-yin deficiency. The disease locations whose occurrences frequency are higher than 5% are lung and kidney. The disease nature whose occurrence frequency are higher than 5% are yin deficiency and fire. In the aspect of clinical investigation， the occurrence frequency of the following syndromes are higher than 10%：lung-yin deficiency， qi-yin deficiency， stomach-yin deficiency， liver-kidney yin deficiency. The disease location whose occurrence frequency is higher than 5% is lung. The disease nature whose occurrence frequency are higher than 5% are yin deficiency and fire.Conclusion:Although there are a great number of syndromes when it comes to xerostomia， the syndrome factors of the disease are not complicated， which exerts positive influence on the syndrome differentiation in clinical practice.