With the development of economy and the improvement of living standard，people pay more attention to the development of prolonging life span. Acupuncture and moxibustion therapy is widely used in the prevention and treatment of aging related diseases，and the mechanism of acupuncture therapy has been further explored. According to the acupuncture involved in scavenging free radical damage，delaying the brain aging，immune aging and senescence related genes and proteins，this paper is to review the mechanism of acupuncture and moxibustion on anti-aging in the recent 5-year literature，for promoting the development of clinical acupuncture and moxibustion and expanding new research ideas.