The peptic ulcer (PU) is one of clinical common peptic diseases with the high morbidity and recurrent rate. As complicated in the pathogenesis，pathological features and clinical manifestations in different cases and there is the different between traditional Chinese medicine and modern medicine for the understanding and treatment of peptic ulcer，different clinical therapies may be applied. With the development of traditional Chinese medicine，systematical studies on the efficacy，mechanism and quality control of Chinese medicine prescription through theories，methods and means of modern science and technology provide new ideas to realize the modernization of traditional Chinese medicine. The author is to review the research progress in peptic ulcer by reading related literature in recent years，for providing reference to effective treatment for peptic ulcer and relevant drug research.