This paper takes the herbs in Compendium of Materia Medica as research objects to study traditional Chinese medicine properties and their counteractive and detoxification effect. Methods:In order to study the correlation between drug properties and drug interactions, the paper uses association algorithm to analyze the data. Results:The study finds that “pungent” property is closely related to toxicity, Besides, drugs with “Bitter” and “Cold” properties are easily counteract with others. Conclusion:However, there are no correlation between toxic and none-toxic drug and their counteractive effects.