This paper explored the application of transformation medicine theory in evidence-based acupuncture and the modes and roads of clinical evidence transformation of acupuncture and moxibustion. Through the brief description of the concept and classification of transformation medicine, the features of clinical evidence transformation of acupuncture and moxibustion were analyzed with the characteristics of traditional Chinese medicine （TCM） and the connection between transformation medicine and TCM. Then the thread and related examples of clinical evidence transformation of acupuncture were expounded from four aspects:theory supplement, clinical practice guiding, community promotion and product transformation. Finally, based on the theory of TCM, an integrated multi-path route for clinical evidence transformation of acupuncture was concluded from the perspective of evidence-based acupuncture and moxibustion.