To observe the clinical efficacy of ShenZhePeiQi Combined with WuzhuYu decoction in liver stomach deficiency-cold type of reflux esophagitis Methods: Totally 82 cases of liver stomach deficiency-cold type of reflux esophagitis patients were randomly divided into a treatment group and a control group, 41 cases in each. The control group was given Rabeprazole enteric-coated capsules, and treatment group ShenZhePeiQi Combined with WuzhuYu decoction. Changes of symptoms were observed after treatment, and endoscopic results were compared. Results:The total efficiency of the treatment group was 92.68%, while the control group 73.17%. The treatment group’s curative effect was better than that of the control group （P<0.05）. The two groups’ endoscopy results comparison: the treatment group and the control group’s total efficiency was not statistically significant （P>0.05）, but the total efficiency of the treatment group was better than that of the control group; Comparison of the two groups’ symptoms score: there was significant difference in the 3 symptoms of stomach pain, dysphagia, nausea and vomiting （P<0.05）. Conclusion: In the treatment of liver stomach deficiency-cold type of reflux esophagitis, the curative effect of ShenZhePeiQi Combined with WuzhuYu decoction is better than that by western medicine treatment.